Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome

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Sci Rep. Dec. 21, 2021; 11 (1): 24348. doi: 10.1038 / s41598-021-03877-6.


The repair of the thoracoabdominal aortic aneurysm (TAAA) is associated with a relevant morbidity and mortality rate in the hospital. In this retrospective observational study at a center with serum zinc levels from 33 patients, we investigated the relationship between zinc and patient outcome after TAAA repair. Six patients died during the hospital stay (18%). These patients had significantly reduced zinc levels before the intervention (zinc level before the intervention: 60.09 µg / dl [survivors] vs. 45.92 µg / dl [non-survivors]). Both the post-interventional SOFA score (Sepsis-related organ failure assessment) (on day 2) and the SAPS (Simplified Acute Physiology Score) (on day 2) showed higher score points with low pre-interventional zinc levels. No significant correlation was observed between patient comorbidities and pre-intervention zinc levels, with the exception of peripheral arterial occlusive disease (PAD), which correlated significantly with reduced baseline zinc levels. Septic shock, pneumonia and urinary tract infections were not associated with decreased zinc levels either preoperatively or during therapy. Patients with an undesirable outcome after TAAA repair showed reduced preinterventional zinc levels. We speculate that decreased zinc levels prior to the intervention may be related to a poorer outcome due to poor physical condition and a negatively altered perioperative inflammatory response.

PMID: 34934131 | DOI: 10.1038 / s41598-021-03877-6

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